Test Overview
Test Methodology

Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Monitor therapeutic drug levels; monitor patient compliance; evaluate amitriptyline toxicity.

Reference Range *

Therapeutic: 120-250 ng/mL; Toxic: > 500 ng/mL (sum of Amitriptyline and Nortriptyline).

Test Limitations

Phenothiazines and other tricyclic antidepressants and their metabolites may interfere when administered concomitantly.

Test Details
Days Set Up
Tuesday
Analytic Time

4 hours

Soft Order Code
AMTRP
MiChart Code
Amitriptyline and Nortriptyline Level
Synonyms
  • Elavil
  • Endep
  • Etrafon
  • Triavil
  • Tricyclics, Amitriptyline and Nortriptyline
  • AMITRIPTYLINE/NORTRIPTYLINE LV
  • AMITRIPTYLINE RESULT
  • NORTRIPTYLINE RESULT
  • AMITRIPTYLINE/NORTRIPTYLINE
  • AMIT
  • NORT2
  • AMITRIPTYLINE
  • NORTRIPTYLINE
Laboratory
Chemical Pathology
Section
Drug Analysis
Specimen Requirements
Collection Instructions

Collect blood in a red top or green top tube; do not use SST or PST tube. Centrifuge, aliquot serum or plasma into plastic vial as soon as possible and refrigerate.

Alternate Specimen
Laveder top (EDTA plasma) [11/09]
Rejection Criteria
SST or PST tube not acceptable.
Yellow Top Tube
Red Top Tube
Normal Volume
1 mL serum or plasma
Minimum Volume
0.7 mL serum or plasma
Additional Information

Test includes Amitriptyline and its active metabolite, Nortriptyline.

Billing
CPT Code
80335
Fee Code
KA006
LOINC
Z107-3