Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)
Monitor therapeutic drug levels; monitor patient compliance; evaluate amitriptyline toxicity.
Therapeutic: 120-250 ng/mL; Toxic: > 500 ng/mL (sum of Amitriptyline and Nortriptyline).
Phenothiazines and other tricyclic antidepressants and their metabolites may interfere when administered concomitantly.
- Tricyclics, Amitriptyline and Nortriptyline
- AMITRIPTYLINE/NORTRIPTYLINE LV
- AMITRIPTYLINE RESULT
- NORTRIPTYLINE RESULT
Collect blood in a red top or green top tube; do not use SST or PST tube. Centrifuge, aliquot serum or plasma into plastic vial as soon as possible and refrigerate.
Test includes Amitriptyline and its active metabolite, Nortriptyline.