Update Type: Reference range changed
Test Updated: 05/10/2023
Test Overview
Test Methodology

Electrochemiluminescent Immunoassay

Test Usage

Assessment of adults with cognitive impairment being evaluated for Alzheimer disease and other causes of cognitive impairment.
These assays should not be used to predict the development of dementia or other neurologic conditions or to monitor response to therapies.

Reference Range *

Beta-amyloid (1-42) (Abeta42): >1026 pg/mL; Total-Tau: < or =238 pg/mL; Phosphorylated-Tau 181: < or =21.7 pg/mL; p-Tau/Abeta42: < or =0.023

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Tuesday, Thursday
Analytic Time

2 - 8 days

Soft Order Code
ADEVL
Synonyms
    Laboratory
    Sendout
    Reference Laboratory
    Mayo ADEVL
    Section
    Special Testing
    Specimen Requirements
    Collection Instructions

    1. Perform lumbar puncture and discard the first 1 to 2 mL of cerebrospinal fluid (CSF).
    2. Collect CSF directly into one of the listed collection tubes until the tube is at least 50% full.*
    3. Send CSF specimen in original collection tube. Do not aliquot.
    Send to Specimen Processing refrigerated

    Special Handling

    Test must be collected using the Mayo collection kit, or a polypropylene aliquot tube as a last resort. The conical, screw capped tube form the LP kit IS acceptable to send to Mayo.

    Alternate Specimen
    Mayo aliquot tube with a blue screw cap and blue writing on it
    Normal Volume
    1.5 - 2 mL CSF
    Minimum Volume
    1.5 mL CSF
    Storage Temperature
    Refrigerated preferred, frozen acceptable
    Rejection Criteria
    CSF collected in a polystyrene tube (in the LP kit used here at Michigan Medicine), gross hemolysis, lipemia or icterus
    Additional Information

    Test performed by Mayo Clinic Laboratories

    Billing
    CPT Code
    82234, 84393, 84394
    Fee Code
    AB173, AB174, AB175
    NY State Approved
    No