Test Overview

Test Methodology

Chemiluminescent Immunoassay (CLIA)

Test Usage

CSF levels of AFP are a useful aid in the diagnosis of primary central nervous system (CNS) germ cell tumors (GCTs). These account for approximately 4 % of primary brain tumors in children. AFP elevation in CSF occurs in approximately 70 % of these tumors. Concurrent testing of beta-HCG is recommended to improve the sensitivity for detecting these CNS tumors. CSF levels of AFP will also be elevated with brain metastases of testicular cancer.

Reference Range*

0 - 1 ng/mL

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details

Days Test Performed

Daily, 24 hours

Analytic Time

2 hours

Soft Order Code


MiChart Code

Alpha-Fetoprotein, CSF




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Chemical Pathology

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Specimen Requirements

Offsite Collection Instructions

Collect spinal fluid, refrigerate.

Normal Volume

0.5 mL CSF

Minimum Volume

0.25 mL CSF

Billing Information

Fee Codes

CPT Code




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