Test Overview

Test Methodology

Hydrolysis of Synthetic Chromogenic Substrate, Colorimetric End point.

Test Usage

Providing a more complete assessment of disseminated intravascular coagulation, intravascular coagulation and fibrinolysis, or hyperfibrinolysis (primary fibrinolysis), when measured in conjunction with fibrinogen, fibrin D-dimer, fibrin degradation products, soluble fibrin monomer complex, and plasminogen; Evaluating liver disease or the effects of fibrinolytic or antifibrinolytic therapy; Diagnosing congenital alpha-2 plasmin inhibitor deficiencies (rare).

Reference Range*

80 - 140% (adults). Normal, full-term newborn infants may have borderline low or mildly decreased levels (> or =50%) which reach adult levels within 5-7 days postnatal. Healthy, premature infants (30-36 weeks gestation) may have
mildly decreased levels which reach adult levels in < or =90 days postnatal.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details

Days Test Performed

Monday-Friday, varies

Analytic Time

2-8 days

Soft Order Code




Alpha 2 Antiplasmin
Alpha-2 Proteinase Inhibitor

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Laboratory Reference

Mayo A2PI

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in blue top (citrate) tube. Centrifuge specimen and aliquot citrate platelet-poor plasma into a plastic tube. Centrifuge plasma again and aliquot platelet-poor plasma into a plastic vials (no glass). Freeze plasma immediately at <40 degrees C. Transport frozen specimen on dry ice. Proper collection and handling of specimens is critical; see Coagulation tab of the handbook to ensure that the proper technique is used.


Blue Top Tube

Normal Volume

1 mL plasma

Minimum Volume

0.5 mL plasma

Additional Information

Test is sent to Mayo Medical Laboratories.

Billing Information

Fee Codes

CPT Code




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