Test Overview
Test Methodology

Hydrolysis of Synthetic Chromogenic Substrate, Colorimetric End point.

Test Usage

Providing a more complete assessment of disseminated intravascular coagulation, intravascular coagulation and fibrinolysis, or hyperfibrinolysis (primary fibrinolysis), when measured in conjunction with fibrinogen, fibrin D-dimer, fibrin degradation products, soluble fibrin monomer complex, and plasminogen; Evaluating liver disease or the effects of fibrinolytic or antifibrinolytic therapy; Diagnosing congenital alpha-2 plasmin inhibitor deficiencies (rare).

Reference Range *

80 - 140% (adults). Normal, full-term newborn infants may have borderline low or mildly decreased levels (> or =50%) which reach adult levels within 5-7 days postnatal. Healthy, premature infants (30-36 weeks gestation) may have
mildly decreased levels which reach adult levels in < or =90 days postnatal.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday-Friday, varies
Analytic Time

2-8 days

Soft Order Code
  • Alpha 2 Antiplasmin
  • Alpha-2 Proteinase Inhibitor
Reference Laboratory
Mayo A2PI
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in blue top (citrate) tube. Centrifuge specimen and aliquot citrate platelet-poor plasma into a plastic tube. Centrifuge plasma again and aliquot platelet-poor plasma into a plastic vials (no glass). Freeze plasma immediately at <40 degrees C. Transport frozen specimen on dry ice. Proper collection and handling of specimens is critical; see Coagulation tab of the handbook to ensure that the proper technique is used.

Normal Volume
1 mL plasma
Minimum Volume
0.5 mL plasma
Additional Information

Test is sent to Mayo Medical Laboratories.

CPT Code