Test Overview
Electrophoresis, Colorimetry
Determining the tissue source of increased Alkaline Phosphatase activity in serum and differentiating between liver and bone sources of elevated Alkaline Phosphatase.
Age and sex specific reference ranges provided with report.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Test Details
2 - 5 days
- ALK Phosphatase Fractionation
- Alkaline Phosphatase Isoenzyme, Bone
- Alkaline Phosphatase Isoenzyme, Liver
- Fractionated Alkaline Phosphatase
- Alkaline Phosphatase Isoenzyme, Intestine
Specimen Requirements
Collect blood in an SST or red top tube. Centrifuge within 2 hours of collection, and aliquot serum into a screw capped plastic tube and freeze. Hemolyzed specimens are not acceptable.
Additional Information
Test includes Total Alkaline Phosphatase and Bone, Liver, and Intestine Isoenzymes. Alkaline phosphatase (ALP) has at least nine recognized isoenzymes. Each has varying properties of heat stability, chemical inhibition, and electrophoretic mobility. They include fast (pre-liver), liver, bone, placental, Regan, Nagao, renal, intestinal, and PA. Of primary interest in the laboratory is distinguishing bone from liver. Of secondary interest is the presence of the more heat-stable "tumor" isoenzymes: Regan, Nagao, and renal. Test sent to Mayo Medical Laboratories.