Days Set Up
Wednesday
Analytic Time

1 hour

MiChart Code
APC Resistance
Soft Order Code
APCR

Test Updated:

Synonyms

APC Resistance
APCR
Factor V Leiden Mutation Screen
Protein C Resistance, Activated
ACTIVATED PROTEIN C RESISTANCE
Factor 5 Leiden Mutation Screen

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Test Overview

Test Methodology

Optical detection of clot formation in the Dilute Russell's Viper Venom Time (DRVVT).

Test Usage

Activated Protein C Resistance is associated with a point mutation in the Factor V gene. This mutation slows the inactivation of factor Va by APC causing a hypercoagulable state.

Reference Range

Ratio greater than or equal to 1.7

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Instructions

Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 3 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.

Blue Top Tube
Normal Volume
Full 2.7 mL tube or 1 mL plasma aliquot
Minimum Volume
Full 1.8 mL tube or 1 mL plasma aliquot

Billing Information

CPT Code
85307
Pro Fee Code
 
Insurance Auth Info
 
LOINC
 

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.