Test Overview
Test Methodology

Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Aid in the diagnosis of carcinoid tumors.

Reference Range *

3 - 10 mg/24 hrs (15.6-52.0 uMol/24 hrs).

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday, Thursday
Analytic Time

8 hours

Soft Order Code
5HIAA
MiChart Code
5 HIAA, 24 HR Urine
Synonyms
  • 5-HIAA
  • 5-Hydroxytryptamine Metabolite
  • Hydroxyindoleacetic Acid, 5-
  • Hydroxytryptamine, 5- Metabolite
  • Serotonin Metabolite
Laboratory
Chemical Pathology
Section
Drug Analysis
Specimen Requirements
Collection Instructions

Collect 24 hour urine specimen. Add 25 mL of 50% glacial acetic acid (15 mL for pediatric patients) to container prior to start of collection. Following collection, mix well, measure 24 hour urine volume, aliquot 10 mL into a plastic urine container and refrigerate. Record total 24 hour urine volume and collection dates/times on request form. Specimens with no preservative are also acceptable: add 50% glacial acetic acid to container following collection, mix well and send 10 mL aliquot (preferred); alternatively a non-acidified aliquot will be accepted. Patient should avoid bananas, pineapple, walnuts, chocolate, kiwi, cough medicine and avocados prior to and during collection; also phenothiazines should be withheld for several days prior to collection if possible.

Alternate Specimen
May be collected in plain (no preservative) container and acid added at the end of collection. It is preferred to have acid added as soon as possible at the client site, mixed, and an aliquot sent. A non-acidified aliquot may also be sent. [rev 9/08]
Contraindications
Patient should avoid bananas, pineapple, walnuts, chocolate, kiwi, cough medicine and avocados for 24 hours prior to and during collection; also phenothiazines should be withheld for 3 days prior to collection if possible.
Normal Volume

10 mL aliquot of 24 hour urine collection

Minimum Volume

10 mL aliquot of 24 hour urine collection

Additional Information

Tested using a laboratory developed assay performed on a Waters liquid chromatography tandem mass spectrometry (LC-MS/MS) system. Results determined from different manufacturers and/or methods may not be comparable.

Billing
CPT Code
83497
Fee Code
20314
LOINC
1695-6
NY State Approved
No