Update Type: Test Discontinued
Test Updated: 11/22/2023
Test Overview
Test Methodology


Test Usage

The 14-3-3? protein appears to contribute to the pathologic process of joint erosion and, as such, is an emerging biomarker of joint damage in rheumatoid arthritis (RA) and psoriatic arthritis. Concentrations are significantly higher in people with active joint disease than in those with inactive RA or psoriasis without arthritis. Measurement of 14-3-3? complements RF and CCP antibody tests and may improve diagnostic sensitivity.

Reference Range *

<0.2 ng/mL

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Thursday
Analytic Time

5 - 10 days

Soft Order Code
MiChart Code
Reference Laboratory
Quest Diagnostics Nichols Institute San Juan Capistrano 91455
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in red top tube. Spin and aliquot into a screw capped plastic tube. Send to Specimen Processing at room temperature.

Normal Volume
1 mL serum
Minimum Volume
0.5 mL serum
Storage Temperature
Ambient preferred, refrigerated, and frozen are acceptable
Additional Information

Test sent to Quest Diagnostics Valencia, performed by Quest Diagnostics Nichols Institute San Juan Capistrano

CPT Code
Fee Code