Analytic Time

Turnaround time is approximately two weeks from receipt of the samples for autopsies and approximately three days for biopsies.

MiChart Code
National Prion 14-3-3 Testing
Soft Order Code

Test Updated:


14-3-3 Protein, Spinal Fluid
Creutzfeldt-Jakob Disease

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

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Test Overview

Test Methodology

Real-time quaking-induced conversion assay (RT-QuIC)

Test Usage

Evaluation of patients with rapidly progressive dementia to establish the diagnosis of CJD.

Reference Range


* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Collect CSF and place in a sterile tube or container. Freeze. Test can also be performed on frozen or fixed brain tissue, blood, or urine. Tissue can be from autopsy or biopsy. Please note "Suspected CJD" on all specimens and requisition.

A completed National Prion Disease Pathology Surveillance Center (NPDPSC) test request form available online at must be submitted with the specimen.

Normal Volume
1 mL CSF
Minimum Volume
0.5 mL CSF

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.