Real-time quaking-induced conversion assay (RT-QuIC)
Evaluation of patients with rapidly progressive dementia to establish the diagnosis of CJD.
Measurement of 14-3-3 protein in CSF should not be relied upon exclusively to establish the diagnosis of Creutzfeldt-Jakob disease (CJD). Increased concentrations in CSF have been described in various diseases that affect the CNS.
Turnaround time is approximately two weeks from receipt of the samples for autopsies and approximately three days for biopsies.
- 14-3-3 Protein, Spinal Fluid
- Creutzfeldt-Jakob Disease
Collect CSF and place in a sterile tube or container. Freeze. Test can also be performed on frozen or fixed brain tissue, blood, or urine. Tissue can be from autopsy or biopsy. Please note "Suspected CJD" on all specimens and requisition.
A completed National Prion Disease Pathology Surveillance Center (NPDPSC) test request form available online at https://case.edu/medicine/pathology/sites/case.edu.pathology/files/2021… must be submitted with the specimen.
Test sent to National Prion Survelliance Center, Cleveland, OH. UMHS users may refer to the Infection Control "Hospital Precautions for Creutzfeldt-Jakob Disease Policy" at http://www.med.umich.edu/i/ice/policies/pdfs/cjd/cjd.pdf for more information.