Liquid Chromatography-Tandem Mass Spectometry (LC-MS/MS)
Diagnostic workup of patients with congenital adrenal hyperplasia; Part of metyrapone testing in the workup of suspected secondary or tertiary adrenal insufficiency; Part of metyrapone testing in the differential diagnostic workup of Cushing syndrome.
< or =18 years: <344 ng/dL, >18 years: 10-79 ng/dL.
Ethanol, estrogens (exogenous and pregnancy-related), barbiturates, valproic acid, phenytoin, and exogenous gluco-corticoids may cause impaired response to metyrapone.
3 - 9 days
- Deoxycortisol, 11-
- Compound S
- DEOXYCORTICOSTERONE, SERUM
- 11-Deoxycortisol, Serum
Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into plastic vial and refrigerate. Morning (8 a.m.) specimens are recommended. Indicate time of collection and whether specimen was collected pre- or post- metyrapone.
Test sent to Mayo Medical Laboratories.