Test Overview
Test Methodology

Liquid Chromatography-Tandem Mass Spectometry (LC-MS/MS)

Test Usage

Diagnostic workup of patients with congenital adrenal hyperplasia; Part of metyrapone testing in the workup of suspected secondary or tertiary adrenal insufficiency; Part of metyrapone testing in the differential diagnostic workup of Cushing syndrome.

Reference Range *

< or =18 years: <344 ng/dL, >18 years: 10-79 ng/dL.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Ethanol, estrogens (exogenous and pregnancy-related), barbiturates, valproic acid, phenytoin, and exogenous gluco-corticoids may cause impaired response to metyrapone.

Test Details
Days Set Up
Tuesday
Analytic Time

3 - 9 days

Soft Order Code
DCORT
MiChart Code
11-Deoxycortisol (Sendout)
Synonyms
  • Corticosterone
  • Deoxycortisol, 11-
  • Compound S
  • FDOC
  • Deoxycorticosteroids
  • DEOXYCORTICOSTERONE, SERUM
  • 11-Desoxycortisol
  • DOC
  • 11-Deoxycortisol, Serum
Laboratory
Sendout
Reference Laboratory
Mayo DCORT
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into plastic vial and refrigerate. Morning (8 a.m.) specimens are recommended. Indicate time of collection and whether specimen was collected pre- or post- metyrapone.

Contraindications
There have been occasional reports of Addisonian crisis during 2-day metyrapone testing. For this reason, 2-day metyrapone testing probably should not be performed when plasma cortisol values are less than 3 mcg/dL.
Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.4 mL serum
Additional Information

Test sent to Mayo Medical Laboratories.

Billing
CPT Code
82634
Fee Code
20420
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