Test Overview
Test Methodology

Liquid Chromatography-Tandem Mass Spectometry (LC-MS/MS)

Test Usage

Diagnostic workup of patients with congenital adrenal hyperplasia; Part of metyrapone testing in the workup of suspected secondary or tertiary adrenal insufficiency; Part of metyrapone testing in the differential diagnostic workup of Cushing syndrome.

Reference Range *

< or =18 years: <344 ng/dL, >18 years: 10-79 ng/dL.

Test Limitations

Ethanol, estrogens (exogenous and pregnancy-related), barbiturates, valproic acid, phenytoin, and exogenous gluco-corticoids may cause impaired response to metyrapone.

Test Details
Days Set Up
Tuesday
Analytic Time

3 - 9 days

Soft Order Code
DCORT
MiChart Code
11-Deoxycortisol (Sendout)
Synonyms
  • Corticosterone
  • Deoxycortisol, 11-
  • Compound S
  • FDOC
  • Deoxycorticosteroids
  • DEOXYCORTICOSTERONE, SERUM
  • 11-Desoxycortisol
  • DOC
  • 11-Deoxycortisol, Serum
Laboratory
Sendout
Reference Laboratory
Mayo DCORT
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into plastic vial and refrigerate. Morning (8 a.m.) specimens are recommended. Indicate time of collection and whether specimen was collected pre- or post- metyrapone.

Contraindications
There have been occasional reports of Addisonian crisis during 2-day metyrapone testing. For this reason, 2-day metyrapone testing probably should not be performed when plasma cortisol values are less than 3 mcg/dL.
Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.4 mL serum
Additional Information

Test sent to Mayo Medical Laboratories.

Billing
CPT Code
82634
Fee Code
20420
NY State Approved
No