Posted Date
Effective Date
Test Name Encephalopathy, Autoimmune Evaluation, CSF
Update Type Miscellaneous
CPT Code 86255 x26, 86341, 0432U, 83516
Order Code ENC2

TEST PANEL UPDATE

 

Encephalopathy, Autoimmune Evaluation, CSF

Order Code:                  ENC2

Fee Code:                     AA271, AA270 (CPT 86255 x23, 86341)

New CPT Codes:          86255 x26, 86341, 0432U, 83516                                   

Reference Laboratory:   Mayo ENC2

 

The following changes will be made to the Encephalopathy Autoimmune Evaluation, CSF, assay performed by Mayo Clinic Laboratories effective October 13, 2026:

 

The following tests will be added to the panel:

  • Adenylate Kinase 5 (AK5) IgG, Tissue Immunofluorescence, Spinal Fluid (AK5IC)
  • Metabotropic Glutamate Receptor-5 (mGluR5) IgG, Tissue Immunofluorescence, Spinal Fluid (GL5IC)
  • Kelch-Like Protein 11 Antibody, Cell Binding Assay, Spinal Fluid (KLHCC)
  • Gamma-Amino Butyric Acid Type A (GABA-A) Receptor Antibody, Cell-Binding Assay, Spinal Fluid (GBACC)
  • Ma2 Antibody, ELISA, Spinal Fluid (MA2EC)

 

The following tests will be added to the reflex algorithm:

  • Adenylate Kinase 5 (AK5) IgG, Cell Based Assay, Spinal Fluid (AK5CC) 
  • Adenylate Kinase 5 (AK5) IgG, Tissue Immunofluorescence Titer, Spinal Fluid (AK5TC)
  • Metabotropic Glutamate Receptor-5 (mGluR5) IgG, Cell Based Assay, Spinal Fluid (GL5CC)
  • Metabotropic Glutamate Receptor-5 (mGluR5) IgG, Tissue Immunofluorescence Titer, Spinal Fluid (GL5TC)
  • Kelch-Like Protein 11 Antibody, Immunofluorescence Titer Assay, Spinal Fluid (K11TC)
  • Microtubule-Associated Protein 1B (MAP1B) Antibody, Immunoblot, Spinal Fluid (MP1BC)
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