SPECIMEN HANDLING AND REFERENCE RANGE UPDATE
Lysosomal Storage Disorders Screen, Urine
Order Code: LSDS
Fee Code: AA931, 23386, AA932, AA180 (CPT 83789, 83864, 84377, 82570)
New Fee Code: AA931, 23386, AA932, AB172 (CPT 83789, 86864, 84377, 84275)
Reference Laboratory: Mayo LSDS
Mayo Clinic Laboratories will add new component Sialic Acid, Free and Total, to their Lysosomal Storage Disorders Screen effective December 10, 2024. There will also be changes to specimen collection and handling, reference ranges as follows:
Collection Instructions: Patient Preparation: Do not administer low-molecular weight heparin prior to collection. Baby wipes or wipes containing soaps and lotions should not be used prior to collection because these may interfere with results. Collect a random urine specimen (early morning preferred). Send 12 mL (minimum 3.5 mL) in a clean, plastic container with no metal cap or glued insert. Refrigerate (preferred) up to 15 days or freeze up to 90 days.
Reference Range:
| Dermatan Sulfate: |
< or =1.00 mg/mmol creatinine
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Heparan Sulfate:
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< or =4 years: < or =0.50 mg/mmol creatinine > or =5 years: < or =0.25 mg/mmol creatinine
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Chondroitin-6 Sulfate:
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< or =24 months: < or =10.00 mg/mmol creatinine 25 months-10 years: < or =2.50 mg/mmol creatinine > or =11 years: < or =1.50 mg/mmol creatinine
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Keratan Sulfate:
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< or =12 months: < or =2.00 mg/mmol creatinine 13-24 months: < or =1.50 mg/mmol creatinine 25 months-4 years: < or =1.00 mg/mmol creatinine 5-18 years: < or =0.50 mg/mmol creatinine > or =19 years: < or =0.30 mg/mmol creatinine
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Free Sialic Acid:
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< or =4 weeks: < or =208 mmol/mol creatinine 5 weeks-12 months: < or =104 mmol/mol creatinine 13 months-18 years: < or =100 mmol/mol creatinine > or =19 years: < or =38 mmol/mol creatinine
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| Total Sialic Acid: |
< or =4 weeks: < or =852 mmol/mol creatinine
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