Test Update 744

Posted Date 01/06/2021

Effective Date 01/06/2021

Update Type Reference range changed

CPT Code 87186

Order Code MMLSG

TEST CHANGE

Antibiotic Susceptibility, Slow-Growing Mycobacterium

Order Code: MMLSG

CPT Code: 87186

Referral Laboratory: Mayo Medical Laboratories

Effective January 6, 2021 MLabs Antibiotic Susceptibility, Slow-Growing Mycobacterium (MMLSG) testing will change the reference ranges per Mayo Medical Laboratories. See below.

Current Reference Values
Interpretive Criteria for Mycobacterium avium-intracellulare complex
Antimicrobial Agent	MIC (mcg/mL)
	S	I	R
Clarithromycin	≤ 8	16	≥ 32
Linezolid	≤ 8	16	≥ 32
Moxifloxancin	≤ 1	2	≥ 4
Amikacin (IV)	≤ 16	32	≥ 64
Amikacin (liposomal, inhaled)	≤ 64	--	≥ 128
Ethambutol	No Interpretation Available
Rifabutin	No Interpretation Available
Rifampin	No Interpretation Available
Streptomycin	No Interpretation Available

Interpretive Criteria for Mycobacterium kansasii and other slowly growing mycobacteria
Antimicrobial Agent	MIC (mcg/mL)
	S	I	R
Amikacin	≤ 16	32	≥ 64
Ciprofloxacin	≤ 1	2	≥ 4
Clarithromycin	≤ 8	16	≥ 32
Doxycycline	≤ 1	2-4	≥ 8
Linezolid	≤ 8	16	≥ 32
Moxifloxancin	≤ 1	2	≥ 4
Rifabutin	≤ 2	--	≥ 4
Rifampin	≤ 1	--	≥ 2
Trimethoprim/ Sulfamethoxazole	≤ 2/38	--	≥ 4

New Reference Values
Interpretive Criteria for Mycobacterium avium-intracellulare complex
Antimicrobial Agent	MIC (mcg/mL)
	S	I	R
Clarithromycin	≤ 8	16	≥ 32
Linezolid	≤ 8	16	≥ 32
Moxifloxancin	≤ 1	2	≥ 4
Amikacin (IV)	≤ 16	32	≥ 64
Amikacin (liposomal, inhaled)	≤ 64	--	≥ 128
Clofazimine	MIC Only, No Interpretations Available

Interpretive Criteria for Mycobacterium kansasii and other slowly growing mycobacteria
Antimicrobial Agent	MIC (mcg/mL)
	S	I	R
Amikacin	≤ 16	32	≥ 64
Ciprofloxacin	≤ 1	2	≥ 4
Clarithromycin	≤ 8	16	≥ 32
Doxycycline	≤ 1	2-4	≥ 8
Linezolid	≤ 8	16	≥ 32
Minocycline	≤ 1	2-4	≥ 8
Moxifloxancin	≤ 1	2	≥ 4
Rifabutin	≤ 2	--	≥ 4
Rifampin	≤ 1	--	≥ 2
Trimethoprim/ Sulfamethoxazole	≤ 2/38	--	≥ 4/76
Clofazimine	MIC Only, No Interpretations Available

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