VANILLYLMANDELIC ACID, (VMA)
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Liquid Chromatography - Mass Spectrometry (LC-MS)
Evaluate catecholamine production, useful in the diagnosis of pheochromocytoma and neuroblastoma and in confirmation of elevated catecholamine levels.
24 Hour Urine: VMA: 0-2 years: 0-1.5 mg/24 hrs, 3-9 years: 0-4.0 mg/24 hrs, 10-150 years: 0-10.0 mg/24 hrs; Random Urine: VMA/Creatinine Ratio:
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
24 hour urine collection; Random samples will be accepted on children less than 10 years old, in which case the VMAR test code must be ordered instead of the VMA test code. Instruct patient to void at 8:00am (or 8:00pm) and discard the specimen. Then collect all the urine including the final specimen voided at the end of the 24 hour collection period, i.e., 8:00am (or 8:00pm) the following day. Transport promptly to the laboratory. Container must be labeled with date and time collection started and finished. Refrigerate during collection. Preferred collection container for random urine VMA is a clean cup with no preservatives.
Collect 24 hour urine specimen. Add 25 mL of 50% glacial acetic acid (15 mL for pediatric patients) to container prior to start of collection. Following collection, mix well, measure 24 hour urine volume, aliquot 10 mL into a plastic urine container and refrigerate. Record total 24 hour urine volume and collection dates/times on request form. Specimens with no preservative are also acceptable: add 50% glacial acetic acid to container following collection, mix well and send 10 mL aliquot (preferred); alternatively a non-acidified aliquot will be accepted. Patient should avoid medications, chocolate, fruit, bananas and any vanilla containing substances for 48 hrs prior to beginning collection. Random samples will be accepted on children less than 10 years old, in which case the VMAR test code must be ordered instead of the VMA test code.