Electrochemiluminescence Immunoassay (ECLIA)
Used in diagnosis of hyperthyroidism and Graves' disease.
< or = 1.75 IU/L. At a decision limit of 1.75 IU/L, this assay has 97% sensitivity and 99% specificity for detection of Graves' disease. In healthy individuals and in patients with thyroid disease without diagnosis of Graves' disease, the upper limit of anti-TSHR values are 1.22 IU/L and 1.58 IU/L, respectively (97.5th percentiles).
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Days Test Performed
Monday - Friday
1 - 4 days
Soft Order Code
Thyrotropin Receptor Antibody
Update Type: Specimen collection or handling and/or storage changed
Updated Date: 03/04/2020
Thyrotropin Binding Inhibitory Immunoglobulin
Thyroid Stimulating Immunoglobulin
Thyroid Stimulating Hormone Receptor Antibody
TSH Binding Inhibition Index
Thyrotropin-Binding Inhibition Index
TSH Receptor Antibody
Thyrotropin Receptor Ab
Mayo THYRO (81797)
Looking to Order a Test?
We’ve provided helpful links to make ordering easy.
All specimens should be accompanied by a requisition.
Learn about how to properly label and where to ship specimens.
MLabs provides all the supplies necessary for the collection of specimens.
Visit our provider FAQ and learn about common questions to ordering tests.
Offsite Collection Instructions
Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate. This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference.
1 mL serum
0.8 mL serum
Measures both Thyroid Stimulating Immunoglobulin (TSI) and Thyrotropin Binding Inhibitory Immunoglobulin (TBII), but does not provide information about function. The Thyrotropin Receptor Autoantibody (TRAB) Assay has utility in the differential diagnosis of Graves disease versus toxic nodular goiter. A low-positive TRAB (15-60) upon initial diagnosis is indicative of a high likelihood that a 6-18 month course of anti-thyroid drug medication will result in remission of Graves disease. Conversely, a high-positive TRAB (>80) upon initial diagnosis indicates a low likelihood of disease remission following anti-thyroid therapy. Studies show that 83% of patients with detectable receptor antibody activity (i.e., an elevated TRAB) at the end of a twelve month course of anti-thyroid drug therapy subsequently relapse. Non-elevated TRAB concentrations after twelve months of drug treatment predict remission in 89% of patients at 1 year and in 81% at 3 years after drug withdrawal. In the most current studies, the frequency of an elevated TRAB in patients with confirmed Graves disease ranges from 94-100%. Test sent to Mayo Medical Laboratories.