Days Set Up
Monday - Friday, 8:00am - 4:00pm
Analytic Time

10-14 days

MiChart Code
TFEB Rearrangement by FISH
Soft Order Code

Test Updated:


TFEB gene region 6p21
Renal Cell Carcinoma

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All specimens should be accompanied by a requisition.

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Test Overview

Test Methodology

Fluorescence In Situ Hybridization (FISH)

Test Usage

This test detects rearrangements involving the TFEB gene region (6p21) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using a dual-color break-apart probe (Empire Genomics) to qualitatively assess for the presence of TFEB translocations that are associated with certain subtypes of renal cell carcinoma. Testing for TFEB gene rearrangement may aid in the diagnosis and classification of these tumors.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Submit a formalin-fixed, paraffin block of the renal cancer tissue (with matched benign renal tissue if available); store at room temperature. Please complete a MiChart test request and submit it with the specimen. A Cytogenetics Laboratory Requisition is available online at:….

Collection Offsite

Submit a formalin-fixed, paraffin block of the renal tumor tissue (with matched benign renal tissue if available); store at room temperature.

Minimum Volume

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.