TFEB gene region 6p21
FFPE FISH for TFEB
Renal Cell Carcinoma
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Fluorescence In Situ Hybridization (FISH)
This test detects rearrangements involving the TFEB gene region (6p21) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using a dual-color break-apart probe (Empire Genomics) to qualitatively assess for the presence of TFEB translocations that are associated with certain subtypes of renal cell carcinoma. Testing for TFEB gene rearrangement may aid in the diagnosis and classification of these tumors.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Submit a formalin-fixed, paraffin block of the renal cancer tissue (with matched benign renal tissue if available); store at room temperature. Please complete a MiChart test request and submit it with the specimen. A Cytogenetics Laboratory Requisition is available online at: http://www.pathology.med.umich.edu/handbook/Tables/UM_REQ_CYTOGENETICS….
Submit a formalin-fixed, paraffin block of the renal tumor tissue (with matched benign renal tissue if available); store at room temperature.