Days Set Up
Monday - Thursday
Analytic Time

2 - 7 days

MiChart Code
SYT/SSX Translocation (Synovial Sarcoma) by PCR
Soft Order Code
SYT

Test Updated:

Synonyms

Synovial Sarcoma Translocation Detection
SYTSSX Translocation Assay
SYTSSX
SYT-SSX
SSX Xp11
SYT 18q11
SYTSSXS
SYT
SYTSSX Translocation
MLABEL
t(X;18) Translocation

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Test Overview

Test Methodology

Reverse transcription followed by Polymerase Chain Reaction (PCR) with detection by capillary electrophoresis.

Test Usage

Synovial sarcoma is characterized by the t(X;18)(p11;q11) translocation which occurs in over 90% of cases regardless of histologic subtype. This rearrangement leads to fusion of the SYT (SS18) gene on chromosome 18 with one of several closely related SSX genes located on the X chromosome. Approximately two-thirds of fusions are SYT/SSX1 and one-third SYT/SSX2. Other fusions are rare. Because of their high specificity and prevalence, SYT/SSX fusion transcripts are highly sensitive diagnostic markers for synovial sarcoma. Testing can aid in the differential diagnosis of synovial sarcoma, especially in tumors with unusual histologic or clinical presentations. This test qualitatively detects the SYT/SSX1 and SYT/SSX2 fusion transcripts in fresh/frozen or formalin-fixed paraffin embedded tissues.

Reference Range

Interpretive report provided. The specific fusion transcript type is reported with a positive test result.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

A formalin-fixed, paraffin-embedded tissue block containing an area with a high percentage of neoplastic cells (for micro-/macro-dissection) is preferred. Unstained, UNBAKED slides (5-8, 10-micron slides; 10-15 if few neoplastic cells are present) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.

Collection Offsite

A formalin-fixed, paraffin-embedded tissue block containing an area with a high percentage of neoplastic cells (for micro-/macro-dissection) is preferred. Unstained, UNBAKED slides (5-8, 10-micron slides; 10-15 if few neoplastic cells are present) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.

Normal Volume
Formalin-fixed, paraffin-embedded tissue. Extracted RNA is also acceptable if extracted in a CLIA certified laboratory.
Minimum Volume
 

Billing Information

CPT Code
81401 x2
Pro Fee Code
 
LOINC
21825-5

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.