Days Set Up
Monday - Friday, 8:00am - 4:30pm; Saturday, 8:00am - 12:00noon
Analytic Time

24 - 48 hours

MiChart Code
SCID panel: T,B,NK Quant (CD3,4,8,19,16/56) with 45RA/RO. Restricted to pat
Soft Order Code
SCIDS

Test Updated:

Synonyms

SCID (Severe Combined Immunodeficiency Disorder)
Immunodeficiencies Profile, SCID
Newborn Screen
SCIDS PANEL
SCIDS
SCIDT
SCID Panel Shadow

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

Visit our provider FAQ and learn about common questions to ordering tests.

Test Overview

Test Methodology
 
Test Usage

Evaluation of possible severe combined immunodeficiency. Testing is performed only on infants identified by State of Michigan TREC study as potential SCIDS patients. A full lymphoid cell panel is run, including B and T cell, T subsets, T-memory and naive subsets, and natural killer cell quantitation. Markers include:
[list]
CD3+
CD3+CD4+
CD3+CD8+
CD3-CD16/56+
CD19+
CD3+CD4+CD45RA+
CD3+CD4+CD45RO+
CD3+CD8+CD45RA+
CD3+CD8+CD45RO+
Calculated CD4:CD8 ratio (T4:T8 ratio)
[/list]

Reference Range

[link text="SCIDS reference range.docx" href="/static/apps/handbook/Tables/SCIDS reference range.docx"]
[bold]*Pediatric Reference Ranges from Journal of Allergy and Clinical Immunology, vol. 112, No. 5, 11/2003 and studies performed at Michigan Medicine Flow Cytometry Laboratory. Absolute ranges are calculated utilizing absolute lymphocyte count ranges for the same age groups provided by the hematology laboratory.[/bold]

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Date and time of collection is required on the order.
[list]
Collect blood in both a 3 ml green top sodium heparin AND a lavender top EDTA tube (CBCD).
Transport at room temperature within 4 hours of collection. Do not refrigerate.
A concurrent Complete Blood Count with Differential (CBCD) order should be placed for the patient to be performed on the lavender EDTA tube submitted.
[/list]

Collection Offsite

Testing performed only for University of Michigan registered patients.

Normal Volume
Whole blood: 3 ml added to each tube
Minimum Volume
Whole blood: 1 ml added to each tube tube

Billing Information

CPT Code
86355, 86357, 86359, 86360, 86356 x4
Pro Fee Code
 
LOINC
 

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.