24 - 48 hours
SCID (Severe Combined Immunodeficiency Disorder)
Immunodeficiencies Profile, SCID
SCID Panel Shadow
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Evaluation of possible severe combined immunodeficiency. Testing is performed only on infants identified by State of Michigan TREC study as potential SCIDS patients. A full lymphoid cell panel is run, including B and T cell, T subsets, T-memory and naive subsets, and natural killer cell quantitation. Markers include:
Calculated CD4:CD8 ratio (T4:T8 ratio)
[link text="SCIDS reference range.docx" href="/static/apps/handbook/Tables/SCIDS reference range.docx"]
[bold]*Pediatric Reference Ranges from Journal of Allergy and Clinical Immunology, vol. 112, No. 5, 11/2003 and studies performed at Michigan Medicine Flow Cytometry Laboratory. Absolute ranges are calculated utilizing absolute lymphocyte count ranges for the same age groups provided by the hematology laboratory.[/bold]
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Date and time of collection is required on the order.
Collect blood in both a 3 ml green top sodium heparin AND a lavender top EDTA tube (CBCD).
Transport at room temperature within 4 hours of collection. Do not refrigerate.
A concurrent Complete Blood Count with Differential (CBCD) order should be placed for the patient to be performed on the lavender EDTA tube submitted.
Testing performed only for University of Michigan registered patients.