3 - 10 days
Test Updated:
MRET
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Test Overview
Fluorescence In Situ Hybridization (FISH)
This test detects rearrangements involving the RET gene region (10q11) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using break-apart probes (Abbott Molecular) to qualitatively assess for the presence of RET translocations that occur in non-small cell lung cancer (NSCLC) and thyroid carcinomas. Lung cancer patients with tumors harboring RET rearrangements may benefit from kinase inhibitor therapy.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Specimen Requirements
A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.
A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.