Days Set Up
Analytic Time

4 hours

MiChart Code
Protein S Activity
Soft Order Code

Test Updated:


Protein S Activity, P

Looking to order a test?

We’ve provided helpful links to make ordering easy.

Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

Visit our provider FAQ and learn about common questions to ordering tests.

Test Overview

Test Methodology

Clot-based endpoint assay.

Test Usage

Second order testing for diagnosis of congenital or acquired protein S deficiency, for example, as an adjunct to initial testing based on results of free protein S antigen assay (PSAGF). Evaluating patients with a history of venous thromboembolism.

Reference Range

ADULT: Male: 75 - 140%; Female: 55 - 125%. There are insufficient data concerning protein S activity in neonates, infants, and children, but normal or near normal activity (>= 50%) probably is present by age 3 to 6 months.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

This test is not available to University of Michigan registered patients unless being followed by a coagulation physician specialist. UMHS orders will be changed to Protein S Antigen, Free (PSAGF).

Collection Offsite

Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 3 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.

Blue Top Tube
Normal Volume
Full 2.7mL tube or 1mL plasma aliquot
Minimum Volume
Full 1.8mL tube or 1mL plasma aliquot

Billing Information

CPT Code
Pro Fee Code

Have More Questions?

Explore our helpful billing resources:

Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.