2 - 3 days
Porphyrins, Fractionation, Urine
PORPHYRINS, URINE QUANT
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High-Performance Liquid Chromatography (HPLC) with Fluorometric Detection
Screening test during symptomatic periods for acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria (additional confirmatory testing is required to establish a diagnosis). Screening test to begin assessment for congenital erythropoietic porphyria and porphyria cutanea tarda (additional confirmatory testing is required to establish a diagnosis).
UROPORPHYRINS (octacarboxyl): < or =30 nmol/24 hours. HEPTACARBOXYLPORPHYRINS: < or =9 nmol/24 hours. HEXACARBOXYLPORPHYRINS: < or =8 nmol/24 hours. PENTACARBOXYLPORPHYRINS: < or =10 nmol/24 hours. COPROPORPHYRINS (tetracarboxyl): Males: < or =230 nmol/24 hours; Females: < or =168 nmol/24 hours. PORPHOBILINOGEN: < or =2.2 mcmol/24 hours.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Patient should abstain from alcohol for 24 hours prior to, as well as during, collection. Collect 24 hour urine specimen. Add 5 grams of Sodium Carbonate (1 gram for pediatric patients) to container prior to start of collection; do not use Sodium Bicarbonate. The container should be refrigerated and protected from light as much as possible during collection. Following collection, mix well, measure 24 hour urine volume, aliquot 50 mL into a plastic urine container and freeze. Protect specimen from light. Record total 24 hour urine volume and collection dates/times on request form.