Analytic Time

7 - 10 days

Soft Order Code

Test Updated:


Anti-Phospholipase A2 Receptor Antibody
Phospholipase A2 Receptor Autoantibody

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Test Overview

Test Methodology

Enzyme Linked Immunosorbent Assay (ELISA)

Test Usage

Approximately 75-80% of patients have serum autoantibodies to the M-type phospholipase A2 receptor (PLAR2). In contrast, less than 10% of patients with secondary membranous nephropathy, other forms of glomerulonephritis, as well as healthy individuals are positive for autoantibody to the PLA2R antibody. An increase, decrease or disappearance generally precedes a change in the clinical status, thus the antibody titer has a predictive value with respect to clinical remission, relapse, or risk assessment after kidney transplantation. A test for colocalization of PLA2R and IgG4 of kidney tissue is recommended in seronegative samples to confirm or exclude a diagnosis of PLA2R antibody-mediated MGN.

Reference Range

Positive: >20 U/mL Borderline: 14 to 20 U/mL Negative: <14 U/mL.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements


Collect specimen in an SST tube. Centrifuge, aliquot serum into a screw capped leak-proof container, and freeze.

Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.2 mL serum

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.