Test Overview
Test Usage

Investigating a subacute multifocal neurological disorder without obvious cause, especially in a patient with past or family history of cancer, or smoking history. Directing a focused search for cancer. Investigating neurological symptoms that appear in the course or wake of cancer therapy, and are not explainable by metastasis. Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy. Monitoring the immune response of seropositive patients in the course of cancer therapy. Detecting early evidence of cancer recurrence in previously seropositive patients.

Reference Range *

Interpretive report provided.

Test Limitations

Negative results do not exclude cancer. Test does not detect Ma2 (MaTa) Antibody. Ma2 Antibody has been described in patients with brainstem and limbic encephalitis in the context of testicular germ cell neoplasms. Scrotal ultra-sound is advisable in men who present with unexplained subacute encephalitis.

Test Details
Update Type: Test Down or Delayed
Test Updated: 08/25/2021
Analytic Time

10 - 14 days

Soft Order Code
PAVL
MiChart Code
Paraneoplastic Autoantibody Evaluation
Synonyms
  • Amphiphysin Antibody
  • ANNA-1
  • ANNA-2
  • ANNA-3
  • Anti-Hu
  • Antineuronal Nuclear Antibodies
  • Anti-Ri
  • Anti-Yo
  • Dorsal Root Ganglion Antibody
  • Hu Antibody
  • Neuronal Nuclear Antibody, Type 1
  • Neuronal Nuclear Antibody, Type 2
  • Neuronal Nuclear Antibody, Type 3
  • Paraneoplastic Cerebellar Degeneration (PCD)
  • PCA-1
  • PCA-2
  • PCA-Tr
  • Purkinje Cell Cytoplasmic Antibody, Type 1
  • Purkinje Cell Cytoplasmic Antibody, Type 2
  • Purkinje Cell Cytoplasmic Antibody, Type Tr
  • Ri Antibody
  • Yo Antibody
  • AGNA-1
  • ACh Receptor (Muscle) Binding Antibody
  • P/Q Type Calcium Channel Antibody
  • CRMP-5 IgG
  • Anti Neuronal Nuclear Antibody Type 1, 2, or 3
  • N Type Calcium Channel Antibody
  • AChR Ganglionic Neuronal Antibody
  • Anti-Glial Nuclear Antibody, Type 1
  • Amphiphysin Antibody Western Blot (reflex)
  • Striational (Striated Muscle) Antibody
  • AChR Antibodies
  • Acetylcholine Receptor Antibodies
  • Neuromyelitis Optica (NMO)/Aquaporin-4-IgG (reflex)
  • GAD65 Antibody (reflex)
  • GABA-B-R Antibody (reflex)
  • Neuronal (V-G) K Channel Antibody
  • CRMP-5-IgG Western Blot (reflex)
  • Paraneoplastic Antibody Western Blot (reflex)
  • ARMO
  • ACh Receptor (Muscle) Modulating Antibody (reflex)
  • C5BLOT
  • GAD65
  • AMPA-R Antibody (reflex)
  • WBLOT
  • NMDA-R Antibody (reflex)
  • PAEVAL
  • Paraneoplastic AutoAb Eval, S
  • AMPWB
  • Amphiphysin Ab Western Blot
  • NMOG
  • Neuromyelitis Optica Ab IgG
  • NMOCS
  • Voltage-Gated Potassium Channel Antibody
Laboratory
Sendout
Reference Laboratory
Mayo PAVAL (83380)
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect blood in SST or red top tube. Centrifuge, aliquot serum into a plastic vial and refrigerate. Include relevant clinical information as well as ordering physician name, telephone number, and mailing address. Indicate if order is a follow-up for a previously diagnosed patient; the patient's previously elevated autoantibodies will be performed.

Yellow Top Tube
Normal Volume
4 mL serum
Minimum Volume
2 mL serum
Additional Information

Test includes AChR Ganglionic Neuronal Antibody, Anti-Glial Nuclear Antibody Type 1, Anti-Neuronal Nuclear Antibody Type 1, Anti-Neuronal Nuclear Antibody Type 2, Anti-Neuronal Nuclear Antibody Type 3, Amphiphysin Antibody, CRMP-5-IgG, Neuronal (V-G) K+ Channel Antibody, N-Type Calcium Channel Antibody, P/Q Type Calcium Channel Antibody, Purkinje Cell Cytoplasmic Antibody Type 1, Purkinje Cell Cytoplasmic Antibody Type 2, Purkinje Cell Cytoplasmic Antibody Type Tr, and Striational (Striated Muscle) Antibody.
The following tests are reflexed at an additional charge when indicated: ACh Receptor (Muscle) Binding Antibody (ARAB), ACh Receptor (Muscle) Modulating Antibody (ARMO), AGNA-1 Immunoblot (AGNBS), AMPA-R Ab CBA (AMPCS), AMPA-R Ab IF Titer (AMPIS), Amphiphysin Immunoblot (AMIBS), ANNA-1 Immunoblot (AN1BS), ANNA-2 Immunoblot (AN2BS), CASPR2 IgG CBA (CS2CS), CRMP-5-IgG Western Blot (C5BLO), DPPX Ab CBA (DPPCS), DPPX Ab IFA (DPPIS), DPPX Ab IFA Titer (DPPTS), GABA-B-R Ab CBA (GABCS), GABA-B-R Ab IF Titer (GABIS), GAD65 Antibody (GAD65), LGI1 IgG CBA (LG1CS), mGluR1 Ab CBA (GL1CS), mGluR2 Ab IFA (GL1IS), mGluR1 Ab IFA Titer (GL1TS), NMDA-R Ab CBA (NMDCS), NMDA-R Ab IF Titer (NMDIS), PCA-1 Immunoblot (PC1BS), and/or PCA-Tr Immunoblot (PCTBS).
By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Test sent to Mayo Clinic Laboratories.

Billing
CPT Code
83519 x5, 83520, 86255 x9
Fee Code
AA182 x5, 30966, AA242 x9
Reflex CPT
ARAB 83519 ARMO 83519 AGNBS 84182 AMPCS 86255 AMPIS 86256 AMIBS 84182 AN1BS 84182 AN2BS 84182 CS2CS 86255 C5BLO 84182 DPPCS 86255 DPPIS 86255 DPPTS 86256 GABCS 86255 GABIS 86256 GAD65 86341 LG1CS 86255 GL1CS 86255 GL1IS 86255 GL1TS 86256 NMDCS 86255 NMDIS 86256 PC1BS 84182 PCTBS 84182
Reflex Fee Code
ARAB 32034 ARMO 36137 AGNBS AA881 AMPCS AA195 AMPIS AA196 AMIBS 38138 AN1BS AA882 AN2BS AA883 CS2CS AA331 C5BLO 36140 DPPCS AA483 DPPIS AA489 DPPTS AA484 GABCS AA197 GABIS AA198 GAD65 32140 LG1CS AA330 GL1CS AA485 GL1IS AA490 GL1TS AA486 NMDCS AA192 NMDIS AA194 PC1BS AA884 PCTBS AA885
LOINC
43104-9