Days Set Up
Monday - Saturday
Analytic Time

2 - 5 days

MiChart Code
Osmotic Fragility, RBC (Sendout)
Soft Order Code

Test Updated:


RBC Osmotic Fragility
Osmotic Fragility, RBC

Looking to order a test?

We’ve provided helpful links to make ordering easy.

Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

Visit our provider FAQ and learn about common questions to ordering tests.

Test Overview

Test Methodology

Osmotic Lysis

Test Usage

Suspected hereditary spherocytic hemolytic anemia.

Reference Range

> or =12 months: 0.50 g/dL NaCl (unincubated): 3-53% hemolysis; 0.60 g/dL NaCl (incubated): 14-74% hemolysis; 0.65 g/dL NaCl (incubated): 4-40% hemolysis; 0.75 g/dL NaCl (incubated): 1-11% hemolysis. Reference values have not been established for patients who are <12 months of age.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements


Specimens must be received by performing laboratory within 72 hours of collection. Collect specimen in a lavender top tube. Also collect a normal control specimen in a lavender top tube from an unrelated, non-smoking individual at the same time that the patient is drawn (label "normal control"). Refrigerate both intact specimens; do not transfer blood to other tubes.

Normal Volume
5 mL whole blood
Minimum Volume
2 mL whole blood

Billing Information

CPT Code
Pro Fee Code

Have More Questions?

Explore our helpful billing resources:

Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.