Days Set Up
Monday - Friday
Analytic Time

4 - 5 days

MiChart Code
PCDx, Paradigm Cancer Diagnostic
Soft Order Code
PCDX

Test Updated:

Synonyms

Paradigm NGS Test

Looking to order a test?

We’ve provided helpful links to make ordering easy.

Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

Visit our provider FAQ and learn about common questions to ordering tests.

Test Overview

Test Methodology

NGS (Next Generation Sequencing) of DNA and mRNA; proprietary algorithms and processes; patented LCE (Laser Capture Enrichment) isolation of specific microsubpopulations of FFPE.

Test Usage

Provides precise actionable information about the specific cancer pathways in the patient and associations between the pathways and the specific drugs available that can impact the cancer to allow for more effective decision-making. Paradigm provides custom analysis as well as a broad-spectrum analysis of over 500 nucleotides of interest including Next-Gen Sequencing for DNA mutations, DNA copy number variation, DNA chromosomal inversions, deletions, translocations and mRNA expression. The analysis is driven by supporting data and literature.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Submit a formalin-fixed, paraffin block of tissue containing greater than 40% tumor (minimum 20%); store at room temperature. One of the following samples should be provided: 1. FFPE Block from the most recent surgery or biopsy, containing the most amount of tumor, excluding bone. 2. Incisional or Excisional Biopsy: Biopsies formalin-fixed, paraffin-embedded in a single block 3. Core Needle Biopsy: Biopsies formalin-fixed, paraffin-embedded in a single block 4. Shaves/Curls: Six to ten 10 um thick curls along with H&E stained section of same block. Tissues should be fixed within one hour of surgical resection. The optimal total fixation time is 12-24 hours, using only neutral-buffered formalin. Fixed tissues should be thoroughly dehydrated prior to the embedding process. To access the PCDx requisition, please see: http://www.paradigmdx.org/pcdx/order-pcdx/

Normal Volume
75 mm3 (5 mm x 5 mm x 3 mm) or 4 to 6 needle biopsies containing 40% tumor
Minimum Volume
1 needle biopsy containing 20% tumor (may be unable to complete full profile with minimum specimen)

Billing Information

CPT Code
 
Pro Fee Code
 
LOINC
 

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.