This test is used for monitoring effectiveness of antiresorptive therapy in patients treated for osteoporosis or other metabolic bone disorders or as an adjunct in the diagnosis of medical conditions associated with increased bone turnover.
All units are reported in nmol Bone Collagen Equivalents (BCE). Adult Male: 5.4-24.2 nmol BCE; Adult Female, Premenopausal: 6.2-19.0 nmol BCE.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Some patients who have been exposed to animal antigens, either in the environment or as part of treatment or imaging procedures, may have circulating antianimal antibodies present. These antibodies may interfere with the assay reagents to produce unreliable results.
Days Test Performed
2 - 6 days
Soft Order Code
NTx Serum (Sendout)
Crosslinked N-telopeptide of Type 1 Collagen, Serum
Type I Collagen (NTX), Serum
Collagen Crosslinks, Serum
N-Telopeptide, Cross-Linked, Serum
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Offsite Collection Instructions
Collect specimen in a red top or SST tube from a fasting patient (preferred). Centrifuge, aliquot serum into a plastic vial and freeze.
This test should not be used for the screening or diagnosis of osteoporosis. In patients with other clinical conditions known to affect bone resorption (eg; cancer metastases to bone), interpretation of serum NTx for monitoring response to osteoporosis therapy might be unreliable.
A morning collection from fasting patients is preferred. If not possible, collect the baseline and subsequent specimens under the same circumstances (e.g., at same time of day).
0.5 mL serum
0.1 mL serum
Test sent to Mayo Medical Laboratories.