Days Set Up
Daily, 24 hours
Analytic Time

2 hours

MiChart Code
Soft Order Code

Test Updated:


N Terminal proBNP
ProBNP (B-Type Natriuretic Peptide)

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Test Overview

Test Methodology

Electrochemiluminescence Immunoassay

Test Usage

An aid in in the diagnosis and assessment of severity of congestive heart failure. Both BNP and NT-proBNP are markers of atrial and ventricular distension due to increased intracardiac pressure. Both markers increase in circulating concentration as the severity of heart failure increases, making them equally good markers of the functional stage of heart failure. NT-proBNP is a larger molecule and has a longer half-life that BNP, so its concentration in serum during heart failure will be considerably higher than that of BNP. NT-proBNP is more stable than BNP, so no special precautions such as keeping the sample on ice prior to analysis is required. Also, NT-proBNP is the appropriate assay for those patients being treated with the drug Entresto. This drug is an inhibitor of the protease that degrades the active hormone BNP and thus prolongs its half-life. Patients receiving this drug should be monitored with the NT-proBNP assay to get an accurate assessment of the severity of their heart failure.

Reference Range

Age 0-75 years: <125 pg/mL; age >75 years: <450 pg/mL.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect specimen in an SST or red top tube. Transport to the laboratory for processing.

Collection Offsite

Collect specimen in an SST or red top tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Yellow Top Tube
Red Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.3 mL serum

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.