Wegener's Granulomatosis (Vasculitis)
Antineutrophil Cytoplasmic Ab
Neutrophil Cytoplasmic Ab, TTR
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Indirect Fluorescent Antibody (IFA), human neutrophil substrate
Wegener's granulomatosis is a disease which results in a necrotizing granulomatous vasculitis in the upper and lower respiratory tract as well as in the kidney. The disease has been successfully treated with immunosuppressive drugs. Recently, autoantibodies against neutrophil cytoplasmic antigens have been found in these patients. The antibody is not directed against neutrophil surface antigens. These antibodies have also been observed in microscopic polyarteritis, in systemic lupus erythematosus and in vasculitis. The antibodies correlate best with individuals having a necrotizing crescentic glomerulonephritis with or without systemic illness.
Negative. Pathologists interpretation of results provided. Two patterns have been recognized. True positive NCA is a finely granular pattern which stains all of the cytoplasm; C-Neutrophil Cytoplasmic autoantibodies (C-NCA) have been described in patients with Wegener's granulomatosis, polyarteritis nodosa and some types of crescentic glomerulonephritis. The second pattern shows a strong perinuclear fluorescence but little or no staining in the cytoplasm. This pattern has been attributed to anti-myeloperoxidase. The perinuclear NCA pattern (P-NCA) is associated with vasculitis, but is not as specific for Wegener's granulomatosis as the cytoplasmic (C-NCA) pattern.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.