Test Overview
Test Methodology

Fluorescent Immunoassay

Test Usage

Implementation of this test is limited to AKI risk assessment in post-operative cardiac surgery patients. The Astute Medical NEPHROCHECK® Test System is intended to be used in conjunction with clinical evaluation in ICU patients who currently have, or have had within the past 24 hours, acute cardiovascular and/or respiratory compromise as an aid in the risk assessment for moderate to severe AKI in the next 12 hours of patient assessment. The NEPHROCHECK® Test System is intended to be used in patients 21 years of age or older.

Reference Range *

No specified reference range for this test. The following interpretation will accompany each result as a result level comment:
Nephrocheck AKI Risk Score Interpretation:
Risk Score <0.3 – low risk of developing moderate to severe AKI.
Risk Score 0.3 to 2.0 – moderate risk of developing moderate to severe AKI.
Risk Score >2.0 – high risk of developing moderate to severe AKI.

Test Details
Days Set Up
24 X 7
Analytic Time

2 hours

Soft Order Code
AKIR
Laboratory
Chemical Pathology
Section
Automation
Specimen Requirements
Collection Instructions

Not applicable

Contraindications
A. Urine albumin concentrations above 125 mg/dl interfere with the Nephrocheck results. Urine
albumin above 3000 mg/dl cause an invalid test result. Use caution interpreting results with
significant proteinuria.
B. Urine Bilirubin concentrations above 7.2 mg/dl interfere with the Nephrocheck results. Use caution interpreting results with severe hyperbilirubinemia.
C. Methylene blue at concentrations of 0.49 mg/L interferes with Nephrocheck results
Normal Volume
10 mL aliquot of random urine collection
Minimum Volume
1 mL aliquot of random urine collection
Rejection Criteria
Urine samples delivered to the chemistry department more than 1 hour after collection will be rejected.
Urine samples collected with additives or preservatives will be rejected.
Billing
CPT Code
None
LOINC
88993-1
NY State Approved
No