Test Overview
Test Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Assist in screening for and monitoring mastocytosis and disorders of systemic mast cell activation.

Reference Range *

Age 0-5 yrs: 120 - 510 mcg/g creatinine; age 6-16 yrs: 70 - 330 mcg/g creatinine; age >16 yrs: 30 - 200 mcg/g creatinine.

Test Limitations

Individuals who are taking monoamine oxidase inhibitors (MAOIs) or aminoguanidine will have increased levels of NMH. Results from patients on MAOIs are uninterpretable.

Test Details
Days Set Up
Tuesday, Thursday
Analytic Time

4 - 10 days

Soft Order Code
NMHR
MiChart Code
Histamine, Random Urine (Mayo NMHR)
Synonyms
  • HST-RN
  • HISTAMINE RANDOM URINE
  • NMHIN
  • N-Methylhistamine, Urine
  • NMHDR - Collection Duration
  • NMHTV - Urine Volume
  • NMHU
Laboratory
Sendout
Reference Laboratory
Mayo NMHR
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect random urine. Transfer urine aliquot to a plastic container and refrigerate. Patients should not consume histamine - rich foods (e.g., cheese, chicken liver, eggplant, sauerkraut, sirloin steak, spinach, tomatoes, wine, or yogurt) for 24 hours prior to start of or during urine collection. Indicate if patient is taking an antihistamine.

Alternate Specimen
If specimen is a 24 hr collection, Refrigeration is still preferred, but the following preservatives are also acceptable: 50% acetic acid, Boric acid, 6M HCl, 6M Nitric acid, Sodium bicarbonate
Normal Volume
5 ml urine
Minimum Volume
3 ml urine
Additional Information

Test sent to Mayo Medical Laboratories.

Billing
CPT Code
82542
Fee Code
AA223
NY State Approved
No