Analytic Time

3 - 7 days

Soft Order Code

Test Updated:


ACh Receptor (Muscle) Binding Antibody
AChR Antibodies
ACh Receptor (Muscle) Modulating Antibody
Acetylcholine Receptor Antibodies

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Test Overview

Test Methodology

RIA (Radioimmunoassay)

Test Usage

Recommended for initial investigation of patients presenting at less than age 20 with a defect of neuromuscular transmission. Seropositivity distinguishes congenital (i.e., genetic) MG from acquired MG. Seronegativity does not exclude the diagnosis of autoimmune MG. A minority of patients lacking detectable AChR antibodies have the recently discovered muscle-specific receptor tyrosine kinase (MuSK) antibodies. MuSK antibody testing is available on request.

Reference Range

Muscle AChR Binding Ab: <=0.02 nmol/L; Muscle AChR Modulating Ab: 0 - 20%.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect specimen in a red top or SST tube.

Collection Offsite

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Yellow Top Tube
Normal Volume
2 mL serum
Minimum Volume
1.5 mL serum

Billing Information

CPT Code
83519 x2
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.