3 - 7 days
Update Type: Test Down or Delayed
Test Updated: 09/04/2019
ACh Receptor (Muscle) Binding Antibody
AChR Antibodies
ACh Receptor (Muscle) Modulating Antibody
Acetylcholine Receptor Antibodies
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Test Overview
RIA (Radioimmunoassay)
Recommended for initial investigation of patients presenting at less than age 20 with a defect of neuromuscular transmission. Seropositivity distinguishes congenital (i.e., genetic) MG from acquired MG. Seronegativity does not exclude the diagnosis of autoimmune MG. A minority of patients lacking detectable AChR antibodies have the recently discovered muscle-specific receptor tyrosine kinase (MuSK) antibodies. MuSK antibody testing is available on request.
Muscle AChR Binding Ab: <=0.02 nmol/L; Muscle AChR Modulating Ab: 0 - 20%.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Specimen Requirements
Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.
