Days Set Up
Monday - Friday
Analytic Time

3 - 5 days

MiChart Code
MTHFR C677T Mutation Analysis, B
Soft Order Code
MMTHF

Test Updated:

Synonyms

C677T MTHFR Mutation
Methylenetetrahydrofolate Reductase by DNA Analysis
MTHFR Mutation Detection
MTHFR
MTHFRS
Homocysteine Mutation Detection
A1298C MTHFR Mutation
MLABEL
METHYLENETETRAHYDROFOLATE
MTHINV
Methylenetetrahydrofolate Reductase Mutation

Looking to order a test?

We’ve provided helpful links to make ordering easy.

Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

Visit our provider FAQ and learn about common questions to ordering tests.

Test Overview

Test Methodology

Direct mutation analysis using PCR amplification, signal generation, and release by cleavage of sequence-specific alleles.

Test Usage

Direct mutation analysis for the MTHFR C677T and/or A1298C mutations should be reserved for patients with coronary artery disease, acute myocardial infarction, peripheral vascular artery disease, stroke, or venous thromboembolism who have increased basal homocysteine levels or an abnormal methionine-load test.

Reference Range

Negative

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect blood in a yellow top (ACD solution B) (preferred) or lavender top (EDTA) tube.

Collection Offsite

Collect blood in a yellow top (ACD solution B) (preferred) or lavender top (EDTA) tube. Send intact whole blood specimen at room temperature (preferred) or refrigerated.

Normal Volume
5 mL ACD (solution B) whole blood
Minimum Volume
1 mL ACD (solution B) whole blood

Billing Information

CPT Code
81291
Pro Fee Code
 
LOINC
21709-1

Have More Questions?

Explore our helpful billing resources:

Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.