Analytic Time

10 - 14 days

MiChart Code
MiPS - Mi Prostate Score
Soft Order Code

Test Updated:


Prostate Cancer Risk Assesment

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

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MLabs provides all the supplies necessary for the collection of specimens.

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Test Overview

Test Methodology

Transcription Mediated Amplification (TMA) and Hybrid Protection Assay (HPA)

Test Usage

Adjunct to serum prostate specific antigen (PSA) for risk stratification of patients undergoing prostate biopsy. MPS incorporates serum PSA, urine PCA3 score, and urine TMPRSS2: ERG score in logistic regression models to derive scores giving the risk of detecting high grade (Gleason score >7) prostate cancer on diagnostic needle biopsy.

Reference Range

The TMPRSS2: ERG score ranges from 0 to 100, with higher scores associated with an increased risk of high grade cancer on diagnostic biopsy. The MyProstateScore (MPS) report provides a high grade prostate cancer risk score, indicating the risk of high grade prostate cancer (Gleason score >7) on diagnostic needle biopsy.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements


[image src=/static/apps/handbook/images/pca3andmips.png width=376][subhead]Specimen Collection[/subhead]1. Perform an attentive DRE immediately prior to specimen collection (the specimen should be collected within approximately 1 hour of DRE):
[list order=Y type=a]
Apply firm pressure from the base to the apex and from the lateral to the medial line of the prostate.
Apply enough pressure to depress the surface slightly.
Perform 3 strokes for each lobe.
[/list]2. Instruct patient to collect the FIRST 20 - 30 mL of voided urine (do not catheterize) following the DRE.
3. [bold]Process the specimen within 4 hours of collection[/bold] (if specimen cannot be processed within 15 minutes, store refrigerated or on ice and process within 4 hours).
[subhead]Specimen Processing[/subhead]1. Invert specimen cup 5 times to re-suspend cells.
2. Add 2.3 mL of urine to each of two GEN-PROBE PROGENSA PCA3 Urine Specimen Transport Tubes. [danger]Do not puncture the foil seal on the cap of the Transport Tube.[/danger] The specimen volume must fall between the two black fill lines on the Transport Tube.
3. Tightly re-cap each Urine Transport Tube and gently invert 5 times to mix; do not shake or vortex. The specimen is now a "processed" urine specimen. Refrigerate. Refrigerated specimens must be received by MLabs within 5 days of collection. For longer storage, freeze and ship specimen on dry ice.
4. Label each Transport Tube with the patient’s first and last names as well as a second identifier such as the patient’s date of birth or medical record number.
5. Include serum PSA result and patient history with the specimens.

Obtaining informed consent from the patient prior to genetic testing is strongly recommended. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained by contacting the MLabs Client Services Center at 800-862-7284 or online at

Red Top Tube
Normal Volume
30 mL urine
Minimum Volume
5 mL urine

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.