Days Set Up
Monday - Friday
Analytic Time

4 weeks

Soft Order Code
CLIFS/CLIF2

Test Updated:

Synonyms

CLINICAL ID OF FAMILIAL MUT
CLIFS
CLIFSS
Clin ID Familial Mut Shadow

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

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Test Overview

Test Methodology

DNA is analyzed for the presence of a specific mutation, aberration or variation using an appropriate method; applicable methods include fluorescent dideoxynucleotide sequencing, various SNP-detection methods, and copy number detection using semi-quantitative or quantitative PCR, or blotting.

Test Usage

This assay can be used to detect and/or confirm the presence of a specific mutation, aberration or variation, in a family member of a patient previously tested in the MMGL Molecular Genetics Laboratory, or in another CAP/CLIA-certified clinical laboratory. This test pathway CANNOT be used to confirm a previous result obtained in a research laboratory.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Physicians must contact the MMGL-MGL laboratory at 734-615-2429 prior to sending samples for new testing. A known positive control sample must also be provided. Collect specimen in a lavender top tube. Send intact specimen to the lab within 24 hours. Alternatively, send 5-10 mcg of highly purified genomic DNA (at a concentration of > or = 0.05 mg/mL) in a 1 X T.E (pH 7.5-8) buffer. The laboratory only accepts DNA that was extracted or isolated by and in a CLIA-certified laboratory or a laboratory meeting equivalent requirements as determined by the CAP and/or the CMS. DNA specimens must pass MMGL quality control analysis before use. If the previous testing of the proband was not performed by the MMGL laboratory, please also provide a copy of the clinical molecular genetics report issued by the CLIA-certified testing laboratory, for the proband, patient or family member in which the mutation was previously detected. Obtaining informed consent from the patient (or legally authorized representative) and ordering physician prior to testing is highly recommended for this test. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained by contacting the MMGL Molecular Genetics Laboratory at 615-2429 during business hours Monday - Friday or online at https://mlabs.umich.edu/sites/default/files/2020-01/file/pci-mmgl_infor….

Collection Offsite

Physicians must contact the MMGL-MGL laboratory at 734-615-2429 prior to sending samples for new testing. A known positive control sample must also be provided. Collect specimen in a lavender top tube. Send intact whole blood specimen within 24 hours if stored at room temperature or within 5 days if stored refrigerated. Alternatively, send 5-10 mcg of highly purified genomic DNA (at a concentration of > or = 0.05 mg/mL) in a 1 X T.E (pH 7.5-8) buffer. The laboratory only accepts DNA that was extracted or isolated by and in a CLIA-certified laboratory or a laboratory meeting equivalent requirements as determined by the CAP and/or the CMS. DNA specimens must pass MMGL quality control analysis before use. If the previous testing of the proband was not performed by the MMGL laboratory, please also provide a copy of the clinical molecular genetics report issued by the CLIA-certified testing laboratory for the proband, patient or family member in which the mutation was previously detected. Obtaining informed consent from the patient (or legally authorized representative) and ordering physician prior to testing is highly recommended for this test. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained from the MMGL Molecular Genetics Laboratory by contacting the MLabs Client Services Center at 800-862-7284 or online at https://mlabs.umich.edu/sites/default/files/2020-01/file/pci-mmgl_infor….

Lavender Top Tube
Normal Volume
5 - 10 mL EDTA whole blood or 5-10 µg or highly purified genomic DNA
Minimum Volume
3 mL EDTA whole blood or 3 µg or highly purified genomic DNA

Billing Information

CPT Code
CLIFS: 81403; CLIF2: 81404
Pro Fee Code
 
LOINC
 

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.