Days Set Up
Monday, Thursday
Analytic Time

4 - 6 days

MiChart Code
Methylmalonic Acid, Urine
Soft Order Code

Test Updated:


Methylmalonate, Urine
MMA, Urine

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Test Overview

Test Methodology

Liquid Chromatography-Tandem Mass Spectometry (LC-MS/MS)

Test Usage

Monitor therapy for patients with methylmalonic aciduria. The rate of urinary methylmalonic acid excretion is usually elevated in patients with occult cobalamin deficiency. Methylmalonate accumulates in man when a cobalamin deficiency state exists which is identified by low normal levels of vitamin B12. Quantitation of urine methylmalonate provides for a functional test for adequacy of this vitamin.

Reference Range

< 3.60 mmol/mol creatinine

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect random urine; second voided specimen after an overnight fast.

Collection Offsite

Collect random urine; second voided specimen after an overnight fast. Transfer aliquot to plastic container and freeze. Indicate "urine" on request form.

Normal Volume
4.0 ml
Minimum Volume
1.2 ml

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.