Fractionated Metanephrines, Urine
Fractionation, Metanephrines and Normetanephrines
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Evaluate presence of abnormal catecholamine production, may be elevated when VMA and catecholamines are within normal limits. Useful in the diagnosis of pheochromocytoma, neuroblastoma, ganglioneuroblastoma, and hypertension.
Metanephrines: 0-300 mcg/24 hrs, Normetanephrines: 50-800 mcg/24 hrs
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Patient Preparation: Patient must be off Aldomet (alpha methyldopa) and its derivatives for a period of not less than 5 weeks. This drug will falsely elevate the metanephrines and normetanephrines. A 12 hour overnight collection will be accepted, but reference ranges have been established only for 24 hour collections. 24 hour urine collection: Instruct the patient to void at 8:00am and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24 hour collection period, i.e., 8:00am the next morning. Refrigerate during collection. Screw the lid on securely. Container MUST be labeled with date and time collection started and finished. Transport the specimen promptly to the laboratory. Any test requiring a 24 hour urine collection with 50% glacial acetic acid preservative may also be run on this specimen.
Collect 24 hour urine specimen. Add 25 mL of 50% glacial acetic acid (15 mL for pediatric patients) to container prior to start of collection. Following collection, mix well, measure 24 hour urine volume, aliquot 20 mL into a plastic urine container and refrigerate. Record total 24 hour urine volume and collection dates/times on request form. Specimens with no preservative are also acceptable: add 50% glacial acetic acid to container following collection, mix well and send 20 mL aliquot (preferred); alternatively a non-acidified aliquot will be accepted. Patient must be off Aldomet (alpha methyldopa) and its derivatives for a period of not less than 5 weeks. This drug will falsely elevate the metanephrines and normetanephrines. A 12 hr overnight collection will be accepted, but reference ranges have been established only for 24 hr collections.