Days Set Up
Monday - Friday
Analytic Time

3 - 8 days

MiChart Code
Interleukin 28B Polymorphism Genotype
Soft Order Code

Test Updated:


IL28B Polymorphism Genotype
IL28B Polymorphism (rs12979860)

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

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MLabs provides all the supplies necessary for the collection of specimens.

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Test Overview

Test Methodology

Real-Time Polymerase Chain Reaction (PCR) with Allelic Discrimination Analysis

Test Usage

Predicting responsiveness of genotype 1 hepatitis C viral infections to combined pegylated-interferon and ribavirin-based therapies. Samples may contain donor DNA if obtained from patients who received heterologous blood transfusions or allogeneic blood or marrow transplantation. Results from samples obtained under these circumstances may not accurately reflect the recipient's genotype. For individuals who have received blood transfusions, the genotype usually reverts to that of the recipient within 6 weeks. For individuals who have received allogeneic blood or marrow transplantation, a pretransplant DNA specimen is recommended for testing. For liver transplant patients, the IL28B genotype of the recipient and the donor are independent predictors of sustained virologic response with combined pegylated-interferon and ribavirin therapy.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect specimen in a lavender top tube. Note that this test is available only for outpatients and should be performed only once per patient lifetime on patients who are proven to be HCV positive.

Collection Offsite

Collect specimen in a lavender top tube. Send intact blood at room temperature. Note that this test should be performed only once per patient lifetime on patients who are proven to be HCV positive.

Lavender Top Tube
Normal Volume
3 mL EDTA whole blood
Minimum Volume
0.4 mL EDTA whole blood

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.