Days Set Up
Tuesday, Friday
Analytic Time

8 hours

MiChart Code
IgG 1, 2, 3, and 4
Soft Order Code
GSUB

Test Updated:

Synonyms

IgG1 Quantitation
IgG2 Quantitation
IgG3 Quantitation
IgG4 Quantitation
IGG SUBCLASSES
IGG1
IGG2
IGG3
IGG4
IGG SUBCLASS 1
IGG SUBCLASS 2
IGG SUBCLASS 3
IGG SUBCLASS 4

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Test Overview

Test Methodology

Nephelometry

Test Usage

During evaluation of a patient for possible immunoglobulin deficiency, quantification of IgG, IgA and IgM are usually performed. However, normal levels of these immunoglobulins will not rule out some forms of immunodeficiency. Quantifying the subclasses of IgG may help determine the immune status of a patient with normal total IgG. It is known that some subclasses preferentially react to particular antigens. IgG2 antibodies react to carbohydrate antigens and polysaccharides, including bacterial capsules. IgG4 antibodies react to allergens and parasitic antigens. The latter antibody may represent a non-IgE antibody which could sensitize basophils for release of histamine with production of allergic symptoms. When IgG2 or IgG4 deficiency accompanies IgA deficiency, the patients are particularly prone to suffer from infections. Patients with ataxia telangiectasia can also have deficiency of IgG subclasses. While not a primary screening test, quantification of IgG subclasses can be useful in patients with IgA deficiency, and in individuals with normal levels of IgG but an apparent poor response to pyogenic bacterial infections. The diagnosis is quite likely when IgG and/or IgA levels are low. Patients with these deficiencies usually respond well to gamma globulin replacement therapy. IgG3 has high antiviral activity.

Reference Range

Updated on: 11/28/2017

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect specimen in SST tube.

Collection Offsite

Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.3 mL serum

Billing Information

CPT Code
82787 x4
Pro Fee Code
 
LOINC
Z39-8

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.