Days Set Up
Monday - Thursday
Analytic Time

3-10 days

MiChart Code
IGH/BCL2 t(14;18) Translocation by FISH
Soft Order Code
MIGHB

Test Updated:

Synonyms

MLABEL
MIGHB
BCL2DF
IHG/BCL2 t(14;18) by FISH
t(14;18) Translocation

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Test Overview

Test Methodology

Fluorescence In Situ Hybridization (FISH)

Test Usage

This test detects the IGH/BCL2 t(14;18)(q32;q21) translocation via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using a dual-color dual-fusion probe set (Abbott Molecular) to qualitatively assess for the presence of the IGH/BCL2 translocation that occurs in most follicular lymphomas (FL) and a subset of diffuse large B-cell lymphomas (DLBCL). Testing for the IGH/BCL2 translocation may aid in the diagnosis of these tumors.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.

Collection Offsite

A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.

Normal Volume
Formalin-fixed, paraffin-embedded tissue
Minimum Volume
 

Billing Information

CPT Code
88377-TC
Pro Fee Code
 
LOINC
 

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.