Days Set Up
Monday - Friday, 8:00am - 4:30pm
Analytic Time

5 days

Soft Order Code

Test Updated:


HLA Antibody Screen Mixed
HLA Antibody Screening Class I & II
HLA Class I Low Resolution
New Patient for Plt Support

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

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MLabs provides all the supplies necessary for the collection of specimens.

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Test Overview

Test Methodology

Molecular Typing (Polymerase Chain Reaction with SSOP) and Solid Phase Assays

Test Usage

In general, HLA matched platelets are used to treat those patients who have a poor response to unmatched platelet transfusions. Using SSOP methodology, HLA Class I typing is performed for the -A, -B, and -C loci. Since the presence of HLA antibodies may have an effect on the survival of platelets after transfusion, antibody screening is performed. PRA indicates the degree of reactivity of tested serum in terms of percent of positive reactions when tested against a panel of known HLA phenotypes.

Reference Range

The patient’s HLA Class I typing will be reported. For positive PRA results, the report will define the detected HLA antibody specificities. For negative results, 0% PRA will be reported.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements


Collect specimens in sufficient yellow top (ACD) solution A tube AND SST tubes. Send intact specimens at room temperature. Do not refrigerate or freeze.

Yellow Top Tube
ACD Solution A
Normal Volume
10 mL ACD (solution A) whole blood AND 3 mL serum
Minimum Volume
5 mL ACD (solution A) whole blood AND 3 mL serum

Billing Information

CPT Code
81372, 86828
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.