HLA Class I One Locus (High Resolution)
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Molecular Typing (SSOP)
A severe or even fatal skin reaction has been associated with carbamazepine therapy. Carbamazepine hypersensitivity is significantly more common in patients with HLA-B*1502. This allele is frequent in patients with ancestry from Asia, including South Asian Indians. Patients with ancestry or from these areas should be screened for the HLA-B*1502 allele before treatment with carbamazepine. Treatment with carbamazepine is not recommended for HLA-B*1502 positive patients.
Interpretive report will indicate presence or absence of HLA-B*1502.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Collect specimen in sufficient yellow top (ACD) solution A or EDTA tubes early in the day. Send intact specimen at room temperature. Do not refrigerate or freeze.