Days Set Up
Monday - Friday, 8:00am - 4:30pm
Analytic Time

5 days

MiChart Code
Soft Order Code

Test Updated:


HLA Class I One Locus (High Resolution)
HLA B*1502
B1502 Antigen
Carbamazepine Sensitivity

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All specimens should be accompanied by a requisition.

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Test Overview

Test Methodology

Molecular Typing (SSOP)

Test Usage

A severe or even fatal skin reaction has been associated with carbamazepine therapy. Carbamazepine hypersensitivity is significantly more common in patients with HLA-B*1502. This allele is frequent in patients with ancestry from Asia, including South Asian Indians. Patients with ancestry or from these areas should be screened for the HLA-B*1502 allele before treatment with carbamazepine. Treatment with carbamazepine is not recommended for HLA-B*1502 positive patients.

Reference Range

Interpretive report will indicate presence or absence of HLA-B*1502.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements


Collect specimen in sufficient yellow top (ACD) solution A or EDTA tubes early in the day. Send intact specimen at room temperature. Do not refrigerate or freeze.

Normal Volume
10 mL ACD (solution A) or EDTA whole blood; additional specimen may be required for patients with extremely low white cell counts.
Minimum Volume
5 mL ACD (solution A) or EDTA whole blood; additional specimen may be required for patients with extremely low white cell counts.

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.