Behcet's Disease - HLA B51
HLA Class I One Locus (Low Resolution)
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Molecular Typing (SSOP)
Behcet’s disease is a systemic inflammatory vasculitis, characterised by oral ulcers, genital ulcers, skin lesions and ocular lesions. It can affect the blood vessels of almost any system involving the gastrointestinal and neurological systems. The association of HLA-B51 and Behcet's disease has been reported in patients of many ethnic groups. Approximately 20% of healthy individuals of various ethnic origins are HLA-B51 positive, compared to 50 to 80% of patients with Behcet's disease. The principal hypothesis is thus the generating of an immune response by a specific microbial or environmental antigen in a genetically susceptible HLA-B51 individual, causing in the systemic manifestations of Behcet’s disease.
Interpretive report will indicate presence or absence of HLA-B51.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Collect specimen in sufficient yellow top (ACD) solution A tubes early in the day. Send intact specimen at room temperature. Do not refrigerate or freeze.