Days Set Up
Monday, Wednesday, Friday
Analytic Time

1 - 4 days

MiChart Code
Histone Antibody
Soft Order Code

Test Updated:


Anti-Histone Antibody
Autoantibodies to Histone
Extractable Nuclear Antibody, Histone

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

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Test Overview

Test Methodology

Enzyme Immunoassay

Test Usage

Testing for autoantibodies to total histones is useful for evaluating patients suspected of having drug-induced lupus erythematosus (LE). Such patients will usually have a positive test for histone autoantibodies and a negative test for autoantibodies to double stranded DNA (ds-DNA). Patients with idiopathic LE have positive tests for both types of

Reference Range


* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect specimen in an SST or red top tube.

Collection Offsite

Collect specimen in an SST or red top tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.45 mL serum

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.