Days Set Up
Tuesday, Friday
Analytic Time

4 - 11 days

MiChart Code
Histamine, 24 HR Urine
Soft Order Code

Test Updated:


Histamine, 24-Hour Urine

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All specimens should be accompanied by a requisition.

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Test Overview

Test Methodology


Test Usage

Documentation of immediate hypersensitivity reactions or diagnosis of patients with systemic mastocytosis. Elevated values are seen in patients with anaphylaxis, with urticaria, or following provocative skin tests.

Reference Range

0.006 - 0.131 mg/24 hour

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements


Collect 24 hour urine specimen. Add 30 mL of 6 N HCl (10 mL for pediatric patients) to container prior to start of collection. Following collection, mix well, measure 24 hour urine volume, aliquot 4 mL into a plastic urine container and refrigerate. Record total 24 hour urine volume and collection dates/times on request form. Specimens with no preservative are also acceptable: add HCl to container following collection, mix well and send 4 mL aliquot (preferred); alternatively a non-acidified aliquot will be accepted. Patient should void antihistamines, oral corticosteroids, and substances that block H2 receptors for at least 24 hours prior to specimen collection.

Red Top Tube
Normal Volume
4 mL aliquot of 24 hour urine collection
Minimum Volume
2 mL aliquot of 24 hour urine collection

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.