Days Set Up
Monday, Tuesday, Thursday
Analytic Time

2 days

Soft Order Code

Test Updated:



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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

Visit our provider FAQ and learn about common questions to ordering tests.

Test Overview

Test Methodology

Enzyme Immunoassay (monoclonal-based competitive binding EIA) after chemical derivatization by acylation.

Test Usage

Histamine measurements are often useful in evaluating patients with suspected anaphylaxis, mastocystosis, gastrointestingal disease, reactions to radiocontrast media, and drug induced anaphlactoid reactions. Additional information may also be obtained by measuring the concentration of tryptase, a mast cell enzyme. Unlike histamine, tryptase is not found in basophils.

Reference Range

<1.0 ng/mL

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements


Collect specimen in a lavender top tube. Immediately place on ice. Centrifuge, aliquot plasma into a plastic vial within 20 minutes of collection and freeze.

Normal Volume
1 mL EDTA plasma
Minimum Volume
0.5 mL EDTA plasma

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.