Days Set Up
Monday - Friday
Analytic Time

42 days

MiChart Code
Familial Hemophagocytic Lymphohistiocytosis Panel
Soft Order Code

Test Updated:


HLH panel

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

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Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

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Test Overview

Test Methodology

Next-Generation Sequencing

Test Usage

This panel detects most known genetic causes of HLH: familial hemophagocytic
lymphohistiocytosis (PRF1, UNC13-D, STX11, STXBP2), X- linked lymphoproliferative (XLP) syndromes 1 and 2 (SH2D1A and XIAP), ITK deficiency (ITK), HermanskyPudlak syndrome types 2 and 9 (AP3B1 and BLOC1S6), Chediak-Higashi syndrome (LYST), CD27 deficiency (CD27), XMEN syndrome and lysinuric protein intolerance (SLC7A7). Mutations in MAGT1 have not been associated with HLH to date, but it is included in this panel to gain knowledge about its association. All inherited as autosomal recessive conditions except for XMEN syndrome and XLP1 and 2, which are inherited as X-linked disorders.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements


Specimens are accepted Monday through Thursday between 12:00 noon and 4:00 pm only and must be received by the performing laboratory within 24 hours of collection. Collect specimen in a lavender top tube. Send intact whole blood at room temperature. Do not refrigerate or freeze.

Lavender Top Tube
Normal Volume
5 mL EDTA whole blood
Minimum Volume
3 mL EDTA whole blood

Billing Information

CPT Code
81404, 81479 x13
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.