Days Set Up
Monday - Friday
Analytic Time

1 day

Soft Order Code
ENA5/ENA7/ENA10

Test Updated:

Synonyms

SmRNP Antibody
RIBOP
ENAB
Sjogren's Antibodies
U1RNP Antibody
Centromere B Antibody
Anti-Centromere
Scl-70 Antibody
SCL-70
ANTI SCLERODERMA AB TO 70 AG
JO-1
AUTOANTIBODIES TO JO1 ANTIGEN
ANTI-RNP
RNP
ANTI-SmRNP
SMRNP
ANTI-SM
CENT B
SS-B
ANTI-SSA/ANTI-RO
ENA (ANTI SS-A/ANTI SS-B)
SMRN
ENA (ANTI-Sm/SmRNP/RNP)
ENA5
ENA (Anti-SM/RNP/SS-A/SS-B)
ENA7
ENA 7 ANTIBODY PANEL
SMITH
CENTROMERE B
ANTI-SSB/ANTI-LA
SS-A
ENA11
ENA 11 ANTIBODY PANEL
CHROM
CHROMATIN
RIBO P
RIBOSOMAL PROTEIN
SSASSB
Anti-Scl 70
Sjogrens syndrome-A extractable nuclear Ab
Autoantibodies to Jo-1 Antigen
Jo-1 Antibody
Chromatin Antibody
Ribosomal Protein Antibody
Anti-SSB (La)
Anti-SSA (Ro)
Ro Antibody
La Antibody
RNP Antibody
Anti-Ro (SSA)
Anti-RNP (Ribonucleoprotein)
Anti-Sm (Smith)
Sm (Smith) Antibody
Anti-La (SSB)
SS-A Antibody
SS-B Antibody
Anti-SmRNP
Anti-Jo 1
Scleroderma Antibody
EXTRACTABLE NUCLEAR ANTIBODIES
Anti-Synthetase Syndrome
Anti-HisRS (Jo-1)
Anti-tRNA Synthetase
Sjogrens syndrome-B extractable nuclear Ab
Ribonucleoprotein extractable nuclear Ab
Smith extractable nuclear Ab
SCL70
JO1
CENTB
RIBOP
SSA
SSB
SSAB
ENA10

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Test Overview

Test Methodology

Multiplex Flow Immunoassay

Test Usage

Useful diagnostic and prognostic information can be gained in ANA positive patients by knowing the specificity of the autoantibodies that are detected. Ideally, collagen vascular disease diagnosis is based on a combination of clinical symptoms and laboratory testing. It is not cost effective to follow up every positive ANA with assays for all 10 possible detectable antibody specificities. MLabs promotes a more cost effective strategy an ENA 5 Antibody Panel (includes SS-A, SS-B, Sm, RNP, and SmRNP) (order code ENA5). These antibodies will account for the vast majority of significant positive results. Other ENA antigens such as Scl-70, Centromere B, Jo-1, and Ribosomal P should not be routinely screened for, but ordered as individual tests as the differential diagnosis dictates. The laboratory recommends either anti-dsDNA (order code ADNA) or crithidia DNAIFA (order code DNAIF) to detect and quantify anti-dsDNA.

Reference Range

Negative

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Onsite

Collect specimen in SST tube. Please indicate panel or specific antibody testing to be performed.

Collection Offsite

Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate. Please indicate panel or specific antibody testing to be performed.

Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.25 mL serum

Billing Information

CPT Code
86235 EACH ANTIBODY
Pro Fee Code
 
LOINC
Z32-3 ENA5, Z1002-5 ENA7, 8076-2 JO-1, 8092-9 SCL-70, 16137-2 CENT B, Z1001-7 CHROM, 5130-0 DSDNA, 31592-9 RIBO P

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.