1 day
Test Updated:
Smith Antibody
Anti-SmRNP
Anti-Sm (Smith)
RNP Antibody
SmRNP Antibody
U1RNP Antibody
SMRN
ANTI-SmRNP
ANTI-RNP
RNP
ANTI-SM
SMITH
Sm (Smith) Antibody
SMRNP
ENA (ANTI-Sm/SmRNP/RNP)
ENA 3 Antibody Panel
Anti-RNP (Ribonucleoprotein)
EXTRACTABLE NUCLEAR ANTIBODY
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Test Overview
Multiplex Flow Immunoassay
Antibodies to the Sm antigen represent a highly specific marker for SLE, but only occur in 25 - 35% of patients with the disease. Antibodies to RNP occur in 30 - 40% of patients with SLE, but are not specific for SLE. Antibodies to RNP are present in nearly all patients with Mixed Connective Tissue Disease (MCTD), and are specific for this disorder when all other antibodies are negative. The Sm and RNP antigens are closely associated, part of a protein and small nuclear RNA complex. The Bioplex 2200 ANA screen test system has beads coated with affinity purified Sm, with recombinant antigens RNP-68 and RNP-A, and a separate bead coated with Sm/RNP combined purified antigen.
Negative
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.