Days Set Up
Monday - Saturday
Analytic Time

2 - 4 days

MiChart Code
Estrogens, Fractionated
Soft Order Code

Test Updated:


Estrogens, E1+E2, Fractionated

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Test Overview

Test Methodology


Test Usage

Estrogens are important in the development and maintenance of the female sex organs and secondary sex characteristics. They also regulate the menstrual cycle and are important in the maintenance of pregnancy. Estradiol is the most potent naturally occurring estrogen. Estradiol is normally metabolized into estrone, which in turn can be metabolized along two alternative pathways eventually to either estriol or 2-methoxyestrone. The direction of estradiol metabolism is altered in hyperthyroidism and anorexia nervosa in increased formation of 2-hydroxyestrone and subsequently 2-methoxyestrone. This causes a consequent decrease in the formation of estriol.

Reference Range

Age and sex specific reference ranges provided with report. Includes Estrone (E1) and Estradiol (E2).

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements


Collect specimen in red top tube; do not use SST tube. Centrifuge and aliquot serum into a plastic vial within 2 hours of collection. Refrigerate.

Yellow Top Tube
Red Top Tube
Normal Volume
1.2 mL serum
Minimum Volume
0.8 mL serum

Billing Information

CPT Code
82670, 82679
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.